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What is meant by reverse tolerance in substance use?

  1. Needing more of a substance to achieve the same effect

  2. Experiencing stronger effects from smaller doses of a substance

  3. Developing an aversion to a previously enjoyed substance

  4. The process of withdrawing from a substance gradually

The correct answer is: Experiencing stronger effects from smaller doses of a substance

Reverse tolerance refers to the phenomenon where an individual experiences stronger effects from smaller doses of a substance over time, rather than needing to consume more to achieve the same effect. This can occur due to various physiological changes in the body, such as heightened sensitivity to the drug or alterations in metabolism. In certain cases, as a person continues to use a substance, their body may react more intensely to it, leading to an overall increase in sensitivity. This is distinct from typical tolerance, where a person requires larger quantities of a substance to achieve similar effects. The other options describe different aspects of substance use: needing more of a substance pertains to standard tolerance, developing an aversion involves a psychological response to a substance, and gradual withdrawal describes the process of reducing substance intake to manage dependence. These concepts are separate from reverse tolerance, which specifically highlights increased sensitivity rather than changes in dosage needs.